This article is from the WebMD Feature Archive
Causes of Obesity in Men
Can genes cause obesity in men? continued...
We all know a few men who can quaff and stuff it all in their wooden legs and still weigh what they did in college. Some people are more predisposed to gain more weight than others, and research indicates that gaining weight rapidly as an infant is associated with a higher risk of adult obesity.
“We don’t know whether the weight gain in infancy is a cause of obesity, or whether they are both controlled by the same gene or perhaps by cultural practices,” says Nicolas Stettler, MD, MSCE, a professor of pediatrics at the University of Pennsylvania. But it may well be that some of us developed metabolic patterns in infancy that continue to influence our eating habits throughout life.
But genes don’t explain the increase in obesity. “I think we can safely say that at the end of the day, the cause of obesity is eating more than you need for your physical activity,” says Stettler. “We eat more, and the availability of more sedentary entertainment leads people to be more sedentary.”
Bigger portions breed bigger appetites which can lead to obesity
Men eat 70% more at a sitting than women do, Rolls tells WebMD. But, she says, men are “the primordial eating machines.” They tend to listen to their bodies more while women eat what they think they are supposed to eat.
The biggest change in eating habits, Rolls believes, is portion size, which started growing in the 1970s in restaurants and recipe books. Then supersizing really took off in the 1980s. It might seem logical to assume that when a person eats a really big meal that person will back off on subsequent meals or days. But Rolls’ research has shown this not to be the case.
At her laboratory, she feeds human test subjects large portion sizes without telling them and observes how they respond. They respond by pigging out. Over a period of 11 days, in a recent experiment, the overfed group sucked up 5,000 more calories than the “control” group, which was given healthy, complete meals but with half the portion size.
Obviously, there are vested interests in favor of selling more food and drink, even if that does help fuel the obesity epidemic. “From the popcorn stand in movie theaters to fast food, we’ve been had by the most skilled advertising people in the world,” says Blackburn. “They keep telling us that it’s our right to be instantly gratified. Well, there’s a sucker born every minute, and you’re a sucker to let yourself gain more than 20 pounds in 20 years.”
Fighting back: How bigger portions can be used to stem the rise in obesity
When it comes to finding solutions to the fat epidemic, Rolls has done some pragmatic thinking. Her research told her that it would be difficult to convince people to eat smaller meals. So what she has done is focused on encouraging them to eat less energy-dense meals.
Indication
Uroxatral® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH.
Important Safety Information
Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir.
UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure. There may be an increased risk of low blood pressure and fainting when taking UROXATRAL in combination with blood pressure medication or nitrates, or erectile dysfunction medication.
If considering cataract surgery (clouding of the eyes), tell your eye surgeon that you are currently taking UROXATRAL or have previously been treated with an alpha-blocker.
Before taking UROXATRAL, tell your doctor if you have kidney problems.
Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval.
BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer.
The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness.
Please see UROXATRAL full prescribing information.

