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Kennedy Disease
Important
It is possible that the main title of the report Kennedy Diseaseis not the name you expected.
Synonyms
- X-linked Spinal and Bulbar Muscular Atrophy
- KD
- SBMA
- Spinal and Bulbar Muscular Atrophy
Disorder Subdivisions
- None
General Discussion
Kennedy Disease is a rare, slowly progressive muscular disorder that affects males only and is inherited as an X-linked genetic trait. Uncontrollable twitching (fasciculations) followed by weakness and wasting of the muscles becomes apparent sometime after the age of fifteen. The muscles of the face, lips, tongue, mouth, throat, vocal chords, trunk and limbs may be affected. Very large calves may also be found in some patients with this disorder. Kennedy disease is caused by a mutation in the androgen receptor (AR) gene. Androgen insensitivity leads to abnormal swelling of the breasts (gynecomastia), small testes and infertility.
Resources
National Ataxia Foundation
2600 Fernbrook Lane n, Suite 119
Minneapolis
MN
55447-4752
USA
Tel: (763)553-0020
Fax: (763)553-0167
naf@ataxia.org
http://www.ataxia.org
Families of Spinal Muscular Atrophy
P.O. Box 196
Libertyville
IL
60048
Tel: (847)367-7620
Fax: (847)367-7623
800: (800)886-1762
sma@fsma.org
http://www.curesma.com
Muscular Dystrophy Association
3300 E. Sunrise Dr
Tucson
AZ
85718
USA
Tel: (520)529-2000
Fax: (520)529-5300
800: (800)344-4863
mda@mdausa.org
http://www.mdausa.org
National Institute of Neurological Disorders and Stroke (NINDS)
31 Center Drive
8A07
Bethesda
MD
20892-2540
Tel: (301)496-5751
Fax: (301)402-2186
800: (800)352-9424
braininfo@ninds.nih.gov
http://www.ninds.nih.gov/
Kennedy's Disease Association
PO Box 1105
Coarsegold
CA
93614-1105
Tel: (559)658-5950
Fax: (559)658-5950
info@kennedysdisease.org
http://www.kennedysdisease.org
MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
150 Custer Court
Green Bay
WI
54301-1243
USA
Tel: (920)336-5333
Fax: (920)339-0995
800: (877)336-5333
mums@netnet.net
http://www.netnet.net/mums/
For a Complete Report:
This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org
Last Updated: 5/5/2008
Copyright 1994, 1996, 2003 National Organization for Rare Disorders, Inc.
WebMD Medical Reference from the National Organization of Rare Disorders
Indication
Uroxatral® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH.
Important Safety Information
Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir.
UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure. There may be an increased risk of low blood pressure and fainting when taking UROXATRAL in combination with blood pressure medication or nitrates, or erectile dysfunction medication.
If considering cataract surgery (clouding of the eyes), tell your eye surgeon that you are currently taking UROXATRAL or have previously been treated with an alpha-blocker.
Before taking UROXATRAL, tell your doctor if you have kidney problems.
Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval.
BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer.
The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness.
Please see UROXATRAL full prescribing information.
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