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Human Anatomy

Male Anatomy of Reproduction: The Prostate

Picture of the Prostate

Side View of the Prostate

The prostate is a walnut-sized gland located between the bladder and the penis. The prostate is just in front of the rectum. The urethra runs through the center of the prostate, from the bladder to the penis, letting urine flow out of the body.

The prostate secretes fluid that nourishes and protects sperm. During ejaculation, the prostate squeezes this fluid into the urethra, and it’s expelled with sperm as semen.

The vasa deferentia (singular: vas deferens) bring sperm from the testes to the seminal vesicles. The seminal vesicles contribute fluid to semen during ejaculation.

Prostate Conditions

Prostatitis: Inflammation of the prostate, sometimes caused by infection. In some cases, it is treated with antibiotics.
Enlarged prostate: Called benign prostatic hypertrophy or BPH, prostate growth affects virtually all men over 50. Symptoms of difficult urination tend to increase with age. Medicines or surgery can treat BPH.
Prostate cancer: It’s the most common form of cancer in men (besides skin cancer), but only one in 35 men die from prostate cancer. Surgery, radiation, hormone therapy, and chemotherapy can be used to treat prostate cancer. Some men choose to delay treatment, which is called watchful waiting.

Prostate Tests

Digital rectal examination (DRE): A doctor inserts a lubricated, gloved finger into the rectum and feels the prostate. A DRE can sometimes detect an enlarged prostate, lumps or nodules of prostate cancer, or tenderness from prostatitis.
Prostate-specific antigen (PSA): The prostate makes a protein called PSA, which can be measured by a blood test. If PSA is high, prostate cancer is more likely, but an enlarged prostate can also cause a high PSA.
Prostate ultrasound (transrectal ultrasound): An ultrasound probe is inserted into the rectum, bringing it close to the prostate. Ultrasound is often done with a biopsy to test for prostate cancer.
Prostate biopsy: A needle is inserted into the prostate to take tissue out to check for prostate cancer. This is usually done through the rectum.

Prostate Treatments

Enlarged Prostate Treatment

Alpha-blockers: Alpha-blockers relax the muscles around the urethra in men with symptoms from an enlarged prostate. Urine then flows more freely.
5-alpha-reductase inhibitors: These medications reduce the level of a certain form of testosterone (DHT). The prostate shrinks when less DHT is present, improving urine flow.
Surgery for an enlarged prostate: Usually, medications resolve symptoms of an enlarged prostate, but some men require surgery to improve symptoms and prevent complications.

Prostate Cancer Treatment

Prostatectomy: Surgery for prostate cancer, called a prostatectomy, removes the prostate with the goal of removing all the cancer.
Radiation therapy: Radiation kills prostate cancer cells while minimizing damage to healthy cells.
Radioactive seed implants: Instead of radiation pointed at the prostate from outside the body, radioactive seeds can be implanted into the prostate to kill cancer cells.
Cryotherapy: Cryotherapy involves killing prostate cancer cells by freezing them.
Hormone therapy: Prostate cancer cells grow in response to hormones. Hormone therapy helps block that effect.
Chemotherapy: When prostate cancer is advanced, chemotherapy may help reduce the cancer’s spread.
Watchful waiting: Since prostate cancer is often slow growing, some older men and their doctors hold off on treatment and wait to see if the cancer appears to be growing.
Clinical trials: Through prostate cancer clinical trials, researchers test the effects of new medications on a group of volunteers with prostate cancer.

Prostatitis Treatment

Acute and chronic prostatitis: Depending on the type of prostatitis, treatment includes antibiotics, medications, and/or surgery.

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Reviewed on October 10, 2008

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Prescribing Information

Indication
Uroxatral® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH.

Important Safety Information
Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir.

UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure. There may be an increased risk of low blood pressure and fainting when taking UROXATRAL in combination with blood pressure medication or nitrates, or erectile dysfunction medication.

If considering cataract surgery (clouding of the eyes), tell your eye surgeon that you are currently taking UROXATRAL or have previously been treated with an alpha-blocker.

Before taking UROXATRAL, tell your doctor if you have kidney problems.

Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval.

BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer.

The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness.

Please see UROXATRAL full prescribing information.